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Why do I need Liver Support?
* The accumulation of chemicals
in our body, from the water that we drink and bathe in, the air that we breathe, and the food that we eat, have
been shown to weaken the immune system and contribute to the development of various degenerative diseases. Double Blind Studies have shown significant decreases in degenerative liver damage in patients with
chronic liver disease (cirrhosis of the liver) while using LIVER SUPPORT in as few as 30 days.
Recommended for those who:
* Suffer from Autoimmune Disorders
* Are Cancer Patients with
poor Liver Function
* Are exposed to Environmental
Toxins,
Chemicals or second hand smoke
* Consume Tobacco Products
* Have a history of liver or
gall bladder problems
* Have been taking medications/drugs
* Consume Alcohol
Pharmaceutical
Quality, FDA approved
manufacturing plant and procedures
LIVER and GALL BLADDER SUPPORT
90 caplets (artichoke-liver-detox):
This is an extremely effective
product for detoxifying the liver, normalizing liver metabolism and preventing further
liver damage due to internal and external toxins like alcohol, cigarettes and environmental poison.
2nd Double Blind Study Overview
DECEMBER 12, 1998
COMPARATIVE STUDY BETWEEN A COMPLEX
OF FLAVONOIDS AND POLYPHENOLS CREATED FROM
EXTRACTS OF ARTICHOKE AND SARSAPRILLA AND A PLACEBO IN ALCOHOL RELATED LIVER DISEASE
In a previous study, completed over two
years ago in this same hospital, an extract of artichoke
(Cynara Floridanum) and sarsaparilla (Smilax Aristolochiaefolia) was evaluated in addressing the
symptoms related to alcoholic liver disease. This study was accomplished over a fifteen-day period
with exceptional results. Because of these results noted over a very short period of time, the hospital
researchers were anxious to set up the same study over a longer period (30 days).
ASCITES
(accumulation of serous fluid in the
spaces between tissues and organs in the cavity of the abdomen)
A 72.38% reduction of the accumulation of serous abdominal fluid was noted in the treated group. The placebo saw
a 6.35% increase in abdominal fluid.
ENCEPHALOPATHY
(a disease of the brain)
A 66.08% reduction of symptoms related
to encephalopathy was noted in the treated group. The placebo group saw
a 12.24% increase in these symptoms.
HEPATOMEGALY
(enlargement of the liver)
The treated group experienced a 93.33%
reduction in enlarged livers. In the placebo group their livers continued
to enlarge by another 7.14%.
SPLENOMEGALY
(enlargement of the spleen)
An 88.40% reduction in spleen enlargement
was noted with the treated group.
The placebo group worsened by 11.54%.
WEAKNESS
The treated group noted a 73.64% increase
in strength. There was a decrease in muscle strength
by 7.41% in the placebo group.
PERIPHERAL EDEMA
Edema in the extremities of the treated
patients decreased by 48.21%.
There was no change in the placebo group.
HEMORRHAGES
The treated group noted a 100% decrease
in capillary hemorrhaging in the skin, gums,
and nasal membranes. The placebo group saw an increase of 28.57% in hemorrhaging.
ANOREXIA
Loss of appetite decreased in the
treated group by 76.98%.
The placebo group noted a decrease of 3.70%.
ABDOMINAL WALL VEINS
The treated group experienced a 60.62%
decrease in tortuous veins in the abdomen related to ascites.
The placebo group saw a 3.33% decrease.
PALMAR ERYTHEMA
The treated group noted a 26.67% decrease
in red and swollen palms.
In the placebo group there was no change.
TELANGIECTASIA
(dilatation of capillary vessels &
arterioles that often forms an angioma)
A 60.00% reduction in vascular lesions
was noted in the treated group.
A 3.33% reduction was seen in the placebo group.
TOTAL BILIRUBIN
(a reddish yellow water insoluble pigment
occurring especially in bile and blood
and causing jaundice if accumulated in excess)
The treated group noted a reduction
of total bilirubin by 38.95%. The placebo group increased by 5.68%.
ALKALINE PHOSPHATASE
(any of the phosphatases that are optimally
active in alkaline medium and occur in especially
high concentrations in bone, the liver, the kidneys, and the placenta)
The treated group obtained
25.91% reduction in alkaline phosphates.
There was an 11.69% increase in the placebo group.
SERUM GLUTAMIC OXALCETIC TRANSAMINASE (SGOT)
(an enzyme promoting transamination)
The treated group noted a decrease
of 23.83% in SGOT levels.
The placebo group experienced a worsening of 11.71%.
PROTHROMBIN TIME
(a plasma protein produced in the liver
in the presence of vitamin K and converted
into thrombin in the clotting of blood)
A 42.00% reduction in clotting time was noted with the treated group.
An increase in clotting time was noted in the placebo group of 6.60%.
SERUM ALBUMIN
(a crystallizable albumin or mixture of
albumins that normally constitutes more than half
of the protein in blood serum and serves to maintain the osmotic pressure of the blood)
An increase of 37.27% in serum albumin was noted in the treated group.
There was a decrease in the placebo group of 1.95%.
GAMMA GLUTAMYL TRANSPEPTIDASE (GGT)
The treated group noted a reduction
of 23.79% in GGT.
The placebo group experienced an increase of 9.92%
DEFINTIONS
AND RESULTS
OF PARAMETERS
ASCITES- Effusion and accumulation of serous fluid
in the abdominal cavity.
ENCEPHALOPATHY- a DEGENERATIVE DISEASE OF THE BRAIN.
HEPATIC ENCEPHALOPATHY- a condition usually occurring
secondarily to advanced disease of the liver. It is marked by disturbances of consciousness that may progress to
deep coma (hepatic coma), psychiatric changes of varying degree, flapping tremor and fetor hepaticas. Also called
portal-systemic encephalopathy.
SPLENOMEGALIA- Enlargement of the spleen.
WEAKNESS- Lacking physical strength or vigor marked
by asthenia, atony, cardiasthena, enervation, fatigue and lassitude.
PERIPHERAL EDEMA- A condition in which the body tissues
contain an excess amount of fluid.
HEMORRHAGES- Bleeding. This was one of the most important
benefits observed in the Liver Support group.
ANOREXIA- Loss of appetite. Seen in depression, malaise,
commencement of fevers and illness, also in disorders of the alimentary tract, especially of the stomach, and as
a result of alcoholic excess and drug addiction.
TOTAL BILIRUBIN LEVEL - The predominant pigment of
human bile. Total serum bilirubin may be increased in cirrhosis of the liver and acute viral hepatitis.
OGT - (Oxalacetic Glutamic Transaminase). It is distributed
all over body tissue, especially in the heart and liver. Fewer amounts are found in the spleen, pancreas, kidneys,
lungs and brain. Any lesion of a tissue leads to the secretion of this enzyme to the blood stream. The activity
of OGT is risen under hepatic necrosis, cirrhosis of the liver or hepatic metastasis.
PROTHROMBINE TIME - A test of clotting time made by
determining the time for clotting to occur after thromboplastin and calcium are added to decalcified plasma. This
is very important data, because it means that Liver Support helps the healing of wounds faster.
SERUM ALBUMIN - One of a group of simple proteins widely
distributed in tissues. Albumin is a constituent of blood. Low levels of albumin in blood plasma are associated
with a pathologic condition of the live.
Liver Support System Ingredient Rationale
A proprietary blend of artichoke (Cynara Floridanum)
and sarsaparilla (Smilax Aristolochiaefolia) that contains the following naturally occurring bioflavonoids and
polyphenols: silymarin, quercetin, catechin, hesperidin, rutin, cynarin, and chlorogenic acid. Bioflavonoids are
a class of water-soluble plant pigments (colors) that have anti-inflammatory, antihistaminic and anti-viral properties.
Health professionals formulated The Liver Support System specifically for detoxifying the liver and gall bladder
and supporting each of their functions.
Included Bioflavonoids
1. Silymarin
Numerous clinical studies have
shown silymarin to be among the most powerful natural agents available for the prevention and treatment of liver
damage caused by exposure to human-made chemicals including alcohol induced liver degeneration and cirrhosis.
References:
Wagner, H., "Antihepatotoxic
flavonoids" in Cody, V., Middleton, E., and Harbourne, J.B., (eds.) Plant Flavonoids in Biology and Medicine:
Biochemical, Pharmacological, and Structure-Activity Relationships, Alan R. Liss. New York, NY, 1986: pp. 545-58.
Salmi, H.A. and Sarna, S. "Effect of Silymarin on chemical, functional, and morphological alterations of the
liver. A double-blind controlled study." Scand J Gastroentrol., 1982, 17: pp.417-21.
Boari, C., Montanari, M., Galleti, G.P., et al. "Occupational toxic liver diseases. Therapeutic effects of
silymarin." Life Sci, 1981, 29: pp. 2,751-5.
2. Quercetin
Quercetin is a bioflavonoid with antioxidant
effects. It is used for the prevention of atherosclerosis, hypercholesterolemia (excess cholesterol in the blood),
and coronary heart disease. It can inhibit carcinogenesis and reduce capillary fragility. Quercetin is used extensively
in the treatment of athletic injuries because it relieves pain and bruising and acts synergistically with Vitamin
C to protect and preserve the structure of capillaries. It also promotes circulation, lowers cholesterol levels
and treats and prevents cataracts. Quercetin fights cancer, diabetes, capillary fragility, and arthritis; stabilizes
membranes; protects against heart disease and allergies; normalizes blood pressure; helps lowers cholesterol; and
slows aging.
References:
Lininger, SW, et al. The Natural
Pharmacy. 1st ed. Rocklin, CA: Prima Publishing; 1998.
Lean ME, Noroozi M, Kelly I. "Dietary flavonols protect diabetic human lymphocytes against oxidative damage
to DNA." Diabetes, (Jan. 1999), 48(1): 176-81.
Encyclopedia of Nutritional Supplements. Prima Publishing, Michael T. Murray, ND, 1996: pp. 324-5.
Satvric, B. "Quercetin in our diet: from potent mutagen to probable anticarcinogen." Clin Biochem 27,
1994: pp.245-8.
Ferrandiz, M.L. and Alcaraz, M.J. "Anti-inflammatory activity and inhibition of arachidonic acid metabolism
by flavonoids." Agents Action 32, 1991: pp.238-287.
3. Catechin
Catechin, another naturally occurring flavonoid,
is similar in effect to silymarin. Catechin is a powerful anti-oxidant that helps prevent free radical oxidative
damage to cells. It also helps in the treatment and prevention of alcohol and chemical-induced liver disease or
damage. Catechin is also valuable for its ability to neutralize intestinal toxins and assist in the stabilization
of cell membranes.
Reference:
Golan, R. Optimal Wellness.
Ballantine Publishing, 1995. P. 179.
4. Hesperidin
Hesperidin has been shown to be useful in
clinical trials as an analgesic and anti-inflammatory.
References:
E.M. Galati, et al. "Biological
effects of hesperidin, a citrus flavonoid. (Note 1): Anti-inflammatory and analgesic activity." Farmaco 40
(11), Nov. 1994: pp. 709-12.
Null, G. "Clinician's Handbook of Natural Healing." Kensington Publications, 1997: pp. 170-71.
5. Rutin
A antioxidant bioflavonoid, free radical scavenger,
and an iron-chelator. It is used as a vascular protector for reducing capillary fragility, permeability, and bleeding;
as a treatment for varicose vein symptoms; and as preventive for stroke (the sudden rupture or clotting/blockage
of a blood vessel to the brain). Some studies show that Rutin offers protection from damage induced by asbestos,
the cytotoxic effects of oxidized low-density lipoproteins (LDL), and gastric injury from ethanol. It also offers
some protection against DNA damage caused by hepatocarcinogens. Rutin is used extensively in the treatment of athletic
injuries because it relieves pain and bruises and acts synergistically with Vitamin C to protect and preserve the
structure of capillaries. It also promotes circulation, lowers cholesterol levels, and treats and prevents cataracts.
Reference:
Kostyuk, V. and Potapovich,
A. "Antiradical and chelating effects in flavonoid protection against silica-induced cell injury." Arch
Biochem Biophys, 355(1), 1998: 43-48.
Schmitt, A., Salvayre, R., Delchambre, J., and Negre-Salvayre, A. "Prevention by alpha-tocopherol and rutin
of glutathione and ATP depletion induced by oxidized LDL in cultured endothelial cells." Br J Pharmacol, 116(3),
1995: 1985-1990.
C Balch, James F., and Balch, Phyllis A. Prescription for Nutritional Healing. Avery Publishing Group, Garden City
Park, NY. 1997: 20.
6. Cynarin
Cynarin assists in the detoxification of the
liver and gall bladder. It also supports the function of these two important organs while and assists in their
regeneration following damage. Cynarin stimulates the clearance of bile from the liver, preventing congestion in
the liver and thus diminishing the chances of liver damage.
Reference:
A. Encyclopedia of Nutritional
Supplements. Prima Publishing, Michael T. Murray, ND, 1996: p. 353.
7. Sarsaparilla
Sarsaparilla has been used in the treatment
of the following conditions: gout, arthritis, digestive disorders, skin diseases, and cancer. Sarsaparilla contains
saponins, which are steroid-like agents that bind with toxins in the digestive tract. Historically, sarsaparilla
has been used as a 'blood purifier' and a general tonic for diseases associated with increased endotoxin levels,
including arthritis, intestinal ulcerative conditions, eczema, and psoriasis.
The tonic effect of sarsaparilla
is the result of its ability to stimulate the removal of accumulated waste products from the cells, blood, and
lymph. These actions tend to increase the health of the entire body and increase vitality, thereby increasing energy
and endurance.
References:
The Natural Pharmacy. Prima
Publishing, Liniger, Wright, Austin, Brown & Gaby, 1998: pp. 305-6.
Herbal Tonic Therapies. Keats
Publishing, Mowrey, D., 1993: p. 354.
8. Chlorogenic Acid (16%)
Chlorogenic Acid is a naturally occurring,
water soluble, phenolic acid that is a potent anti-oxidant, carcinogenic inhibitor and protector against lipid
peroxidation and free radical mediated cell injury.
References:
J Chromatogram A 1996; 741(2):
pp.223-31
Biosci Biotechnol Biochem 1996; 60 (5): pp.
765-68.
Biochem Pharmacol 1987; 36 (5): pp.717-20.
Plant Foods Hum Nutr 1994; 45 (3): pp.287-98.
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